Alopecia Baldness Treatments Spironolactone: Hair Loss in Women

Spironolactone: Hair Loss in Women

Spironolactone for hair loss in women?

The drug Spironolactone, initially developed as a diuretic for high blood pressure, has found its way into the world of beauty.

We already know that spironolactone works very well topically to help control sebum production and acne by blocking DHT (Dihydrotestosterone). And since DHT is the main culprit for Androgenic Alopecia, this makes Spironolactone fit perfectly into hair loss treatment options.

In this article, we will cover the basics of Androgenic Alopecia, what Spironolactone does to help, who can use Spironolactone and in how long we can see results.

What is androgenetic alopecia?

La Androgenic Alopecia it is a very common form of hair loss that is seen in both men and women.


Androgenic Alopecia occurs at similar rates in men and women. Women can hide it a little better due to longer hairstyles and overall preservation of the hairline.

Although there can be a few different causes of androgenic alopecia, including genetics (Sorry, we can't help you on that), one of the biggest reasons for hair loss is an androgen called Dihydrotestosterone (DHT).

DHT is derived from testosterone in the body. It is a natural chemical, too much can cause unwanted hair problems.

And yes, women also have these hormones, albeit in smaller amounts than men.

DHT tends to miniaturize the hair follicle and shorten the hair growth phase. This leads to hair loss and the appearance of thinner and shorter strands in both men and women.

In men, this means an initial thinning of the hair at the crown of the head, along with that characteristic "M" hairline. This can progress to baldness complete.

For women, we typically see average thinning across the entire scalp. They normally maintain a similar hairline and rarely progress to complete baldness.

How does spironolactone work for hair loss?

Now that you know DHT is part of the problem, you want to get rid of it, right?

This is where spironolactone comes in:

Spironolactone helps reduce the effects of DHT by competitively blocking binding to its receptor, helping to prevent miniaturization of hair follicles.

Additionally, spironolactone helps reduce additional adrenal production of androgens in the first place.

Efficacy of Spironolactone for hair loss

A study in women found that spironolactone reduces hair loss and even achieves partial regrowth of hair.

Another study of oral spironolactone found that 80% of women taking the drug couldn't see further progression of hair loss or even hair regrowth.

How long does spironolactone take to work against hair loss?

As with most hair growth medications, due to the slow nature of hair growth, you have to be patient to see the results.

Most people need to use Aldactone for up to 6 months before it actually starts working.

Who can use spironolactone for hair loss?

Oral spironolactone should only be used in women. Men should avoid spironolactone to prevent any risk of feminization. Although topical applications may not reach the entire body in the same way and avoid these adverse side effects.

A study that used topical spironolactone in men and women for skin androgenation found that locally applied spironolactone is very effective as an antiandrogen without having side effects throughout the body.

Another similar study using only male participants and topical spironolactone found that at concentrations of 5%, the effects were only localized.

And this study that made men apply 5% spironolactone to 55% of their body area, states that when spironolactone is applied topically there is only local absorption and there are no hormonal changes.

To be safe, we recommend that all men who intend to use Spironolactone completely avoid oral medications, and that they speak to their doctor before using Spironolactone topical therapy.

Women who are pregnant, nursing, or expecting to become pregnant should avoid all use of spironolactone. It has been shown to have detrimental effects on the feminization of the male fetus.

Your Order Spironolactone and Hair Loss

Androgenic Alopecia is the most common form of hair loss in men and women, and can be caused by excess DHT (Dihydrotestosterone).

To help reduce exposure to DHT in hair follicles, Spironolactone can be used as an antiandrogen.

In studies conducted on women for hair loss, Spironolactone is good enough to reduce further hair loss or increase new hair growth in about 80% of participants.

For most people, you will need to treat for at least 6 months before you can see results, due to the slow nature of hair growth.

Only women should use spironolactone by mouth.

Topical spironolactone formulations are likely to remain local and are unlikely to have absorption or effects throughout the body.

Spironolactone should not be used in pregnant, lactating women, or in the hope of becoming pregnant in the near future.

So now you know everything about Spironolactone Hair Loss.

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Dr. Enrique Orozco
Dr. Enrique Orozco
General Director, Specialist in Trichology and Hair Transplantation Certified by ABHRS. Only ABHRS Certified with residence in Mexico.


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Dr. Enrique Orozco
General Director, Specialist in Trichology and Hair Transplantation Certified by ABHRS. Only ABHRS Certified with residence in Mexico.




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